Multivariate analysis of prognostic factors in patients with lip squamous cell carcinoma after surgery

Lip squamous cell carcinoma (LSCC) was one of the most common cancer types of head and neck tumors. This study aimed to find more predictors of the prognosis in postoperative LSCC patients. A total of 147 LSCC patients between June 2012 and June 2018 were collected from two tertiary care institution...

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Bibliographic Details
Published in:World journal of surgical oncology 2024-01, Vol.22 (1), p.35-35, Article 35
Main Authors: Cheng, Hao, Xu, Jin-Hong, He, Jia-Qi, Yang, Xi-Yang, Shen, Xu-Ning, Xu, Xue-Lian
Format: Article
Language:English
Subjects:
Age
Age-adjusted Charlson comorbidity index
Aged
Biopsy
Body mass index
Cancer
Carcinoma, Squamous Cell - pathology
Care and treatment
Chemotherapy
Comorbidity
Diagnosis
Head & neck cancer
Head and Neck Neoplasms
Hemoglobin
Humans
Inflammation
Laryngeal Neoplasms - pathology
Lip
Lip cancer
Lip squamous cell carcinoma
Lymph nodes
Lymphatic system
Medical prognosis
Metastasis
Multivariate analysis
Nutrition
Nutritional status
Oncology
Oral cancer
Overall survival
Patient outcomes
Patients
Postoperative
Prognosis
Progression-free survival
Radiation therapy
Radiotherapy
Regression analysis
Retrospective Studies
Skin
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck
Subgroups
Surgery
Survival
Tumors
Variables
Citations: Items that this one cites
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Summary:Lip squamous cell carcinoma (LSCC) was one of the most common cancer types of head and neck tumors. This study aimed to find more predictors of the prognosis in postoperative LSCC patients. A total of 147 LSCC patients between June 2012 and June 2018 were collected from two tertiary care institutions. There were 21 clinicopathological factors included and analyzed in our study. The univariate and multivariate Cox regression analyses were performed to find the independent prognostic factors for predicting progression-free survival (PFS) and overall survival (OS) in postoperative LSCC patients. The role of adjuvant radiotherapy in various subgroups was displayed by Kaplan-Meier plots. The 1-, 3-, and 5-year PFS of postoperative LSCC patients were 88.4%, 70.1%, and 57.8%, respectively. Similarly, the 1-, 3-, and 5-year OS of postoperative LSCC patients were 94.6%, 76.9%, and 69.4%, respectively. The results suggested that postoperative LSCC patients with age at diagnosis ≥ 70 years, grade with moderate or poor differentiate, the American Joint Committee on Cancer (AJCC) stage IV, higher systemic immune-inflammation index (SII), surgical margin 
ISSN:1477-7819
1477-7819
DOI:10.1186/s12957-024-03313-9