Inflammatory cytokines mediating the effect of oral lichen planus on oral cavity cancer risk: a univariable and multivariable mendelian randomization study

While observational studies and experimental data suggest a link between oral lichen planus (OLP) and oral cavity cancer (OCC), the causal relationship and the role of inflammatory cytokines remain unclear. This study employed a univariable and multivariable Mendelian Randomization (MR) analysis to...

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Published in:BMC oral health 2024-03, Vol.24 (1), p.375-375, Article 375
Main Authors: Zheng, Tao, Liu, Chengyong, Wang, Yetong, Zhou, Han, Zhou, Rong, Zhu, Xuan, Zhu, Zibing, Tan, Yisi, Li, Zhengrui, Huang, Xufeng, Tan, Jin, Zhu, Keke
Format: Article
Language:English
Subjects:
Causal inference
Cytokines
Datasets
Disease prevention
Genetic diversity
Genomes
Head & neck cancer
Health risks
Inflammation
Inflammatory cytokines
Interleukin 13
Lichen planus
Mendelian randomisation
Observational studies
Oral cancer
Oral carcinoma
Oral cavity
Oral cavity cancer
Oral diseases
Oral lichen planus
Skin diseases
Squamous cell carcinoma
Variables
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Summary:While observational studies and experimental data suggest a link between oral lichen planus (OLP) and oral cavity cancer (OCC), the causal relationship and the role of inflammatory cytokines remain unclear. This study employed a univariable and multivariable Mendelian Randomization (MR) analysis to investigate the causal relationship between OLP and the risk of OCC. Additionally, the potential role of inflammatory cytokines in modulating this association was explored. Instrumental variables were derived from genetic variants associated with OLP (n = 377,277) identified in Finngen R9 datasets, with 41 inflammatory cytokines as potential mediators, and OCC (n = 4,151) as the outcome variable. Analytical methods including Inverse Variance Weighted (IVW), Weighted Median, MR-Egger, and MR-PRESSO were utilized to assess the causal links among OLP, inflammatory cytokines, and OCC risk. Multivariable MR (MVMR) was then applied to quantify the mediating effects of these cytokines in the relationship between OLP and increased OCC risk. MR analysis provided strong evidence of a causal relationship between OLP (OR = 1.417, 95% CI = 1.167-1.721, p 
ISSN:1472-6831
1472-6831
DOI:10.1186/s12903-024-04104-0