Oral microbiome and ischemic stroke risk among elderly Chinese women

Stroke, a leading cause of disability worldwide, has been associated with periodontitis. However, whether stroke risk is related to oral microbiota remains unknown. This study aims to evaluate the associations between the oral microbiome and ischemic stroke risk. In a case-control study of 134 case-...

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Bibliographic Details
Published in:Journal of oral microbiology 2023, Vol.15 (1), p.2266655-2266655
Main Authors: Wang, Cong, Yang, Yaohua, Cai, Qiuyin, Gao, Yutang, Cai, Hui, Wu, Jie, Zheng, Wei, Long, Jirong, Shu, Xiao-Ou
Format: Article
Language:English
Subjects:
Community structure
Dirichlet problem
Gene families
Health risks
Ischemia
Ischemic stroke
Latent Dirichlet Allocation
Metabolic pathways
Metagenomics
microbial sub-community
Microbiomes
Microbiota
Microorganisms
nested case-control study
oral microbiome
Periodontitis
Risk
Statistical analysis
Stroke
Taxa
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Summary:Stroke, a leading cause of disability worldwide, has been associated with periodontitis. However, whether stroke risk is related to oral microbiota remains unknown. This study aims to evaluate the associations between the oral microbiome and ischemic stroke risk. In a case-control study of 134 case-control pairs nested within a prospective cohort study, we examined pre-diagnostic oral microbiome in association with stroke risk via shotgun metagenomic sequencing. The microbial sub-community and functional profiling were performed using Latent Dirichlet Allocation and HUMAnN2. Associations of microbial diversity, sub-community structure, and individual microbial features with ischemic stroke risk were evaluated via conditional logistic regression. Alpha and beta diversities differ significantly between cases and controls. One genus- and two species-level sub-communities were significantly associated with decreased ischemic stroke risk, with odds ratios (95% confidence intervals) of 0.52 (0.31-0.90), 0.51 (0.31-0.84), and 0.60 (0.36-0.99), respectively. These associations were potentially driven by the representative taxa in these sub-communities, ., genus and , and species and (  
ISSN:2000-2297
2000-2297
DOI:10.1080/20002297.2023.2266655