The Role of Cyclodextrins in the Design and Development of Triterpene-Based Therapeutic Agents

Triterpenic compounds stand as a widely investigated class of natural compounds due to their remarkable therapeutic potential. However, their use is currently being hampered by their low solubility and, subsequently, bioavailability. In order to overcome this drawback and increase the therapeutic us...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-01, Vol.23 (2), p.736
Main Authors: Prodea, Alexandra, Mioc, Alexandra, Banciu, Christian, Trandafirescu, Cristina, Milan, Andreea, Racoviceanu, Roxana, Ghiulai, Roxana, Mioc, Marius, Soica, Codruta
Format: Article
Language:English
Subjects:
Alzheimer's disease
Bioavailability
Cancer
Chemical compounds
Chemical Phenomena
Cyclodextrin
Cyclodextrins
Cyclodextrins - chemistry
Cyclodextrins - classification
cytotoxicity
Drug Compounding
Drug Design
Drug Development
Drugs
Formulations
Herbal medicine
Humans
Hydrophobicity
Inclusion complexes
Investigations
Lipophilic
Methods
Molecular Structure
Pharmaceuticals
Pharmacology
phytocompounds
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Review
Solubility
Structure-Activity Relationship
Triterpenes
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
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Summary:Triterpenic compounds stand as a widely investigated class of natural compounds due to their remarkable therapeutic potential. However, their use is currently being hampered by their low solubility and, subsequently, bioavailability. In order to overcome this drawback and increase the therapeutic use of triterpenes, cyclodextrins have been introduced as water solubility enhancers; cyclodextrins are starch derivatives that possess hydrophobic internal cavities that can incorporate lipophilic molecules and exterior surfaces that can be subjected to various derivatizations in order to improve their biological behavior. This review aims to summarize the most recent achievements in terms of triterpene:cyclodextrin inclusion complexes and bioconjugates, emphasizing their practical applications including the development of new isolation and bioproduction protocols, the elucidation of their underlying mechanism of action, the optimization of triterpenes' therapeutic effects and the development of new topical formulations.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23020736