Pyroptosis in the Retinal Neurovascular Unit: New Insights Into Diabetic Retinopathy

Diabetic retinopathy (DR) is prevalent among people with long-term diabetes mellitus (DM) and remains the leading cause of visual impairment in working-aged people. DR is related to chronic low-level inflammatory reactions. Pyroptosis is an emerging type of inflammatory cell death mediated by gasder...

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Published in:Frontiers in immunology 2021-10, Vol.12, p.763092-763092
Main Authors: Meng, Chunren, Gu, Chufeng, He, Shuai, Su, Tong, Lhamo, Thashi, Draga, Deji, Qiu, Qinghua
Format: Article
Language:English
Subjects:
Diabetes Complications - pathology
Diabetes Mellitus, Type 2 - pathology
diabetic retinopathy
Diabetic Retinopathy - pathology
Humans
IL-1β and IL-18
Immunology
inflammation
Interleukin-18 - biosynthesis
Interleukin-1beta - biosynthesis
Microglia - pathology
Obesity - pathology
pyroptosis
Pyroptosis - physiology
Retina - pathology
retinal neurovascular unit
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container_title Frontiers in immunology
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creator Meng, Chunren
Gu, Chufeng
He, Shuai
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description Diabetic retinopathy (DR) is prevalent among people with long-term diabetes mellitus (DM) and remains the leading cause of visual impairment in working-aged people. DR is related to chronic low-level inflammatory reactions. Pyroptosis is an emerging type of inflammatory cell death mediated by gasdermin D (GSDMD), NOD-like receptors and inflammatory caspases that promote interleukin-1β (IL-1β) and IL-18 release. In addition, the retinal neurovascular unit (NVU) is the functional basis of the retina. Recent studies have shown that pyroptosis may participate in the destruction of retinal NVU cells in simulated hyperglycemic DR environments. In this review, we will clarify the importance of pyroptosis in the retinal NVU during the development of DR.
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subjects Diabetes Complications - pathology
Diabetes Mellitus, Type 2 - pathology
diabetic retinopathy
Diabetic Retinopathy - pathology
Humans
IL-1β and IL-18
Immunology
inflammation
Interleukin-18 - biosynthesis
Interleukin-1beta - biosynthesis
Microglia - pathology
Obesity - pathology
pyroptosis
Pyroptosis - physiology
Retina - pathology
retinal neurovascular unit
title Pyroptosis in the Retinal Neurovascular Unit: New Insights Into Diabetic Retinopathy
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