Comparable assessment of adolescent repeated physical or psychological stress effects on adult cardiac performance in female rats

Extensive evidence highlights a robust connection between various forms of chronic stress and cardiovascular disease (CVD). In today's fast-paced world, with chronic stressors abound, CVD has emerged as a leading global cause of mortality. The intricate interplay of physical and psychological s...

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Bibliographic Details
Published in:Scientific reports 2023-09, Vol.13 (1), p.16401-16401, Article 16401
Main Authors: Mousavi, Monireh-Sadat, Meknatkhah, Sogol, Imani, Alireza, Geramifar, Parham, Riazi, Gholamhossein
Format: Article
Language:English
Subjects:
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Adolescents
Cardiovascular disease
Cardiovascular diseases
Cardiovascular system
Child development
Computed tomography
Echocardiography
Glial fibrillary acidic protein
Heart
Humanities and Social Sciences
Hypertrophy
Immunohistochemistry
Inflammation
Influence
Ischemia
Laboratory animals
multidisciplinary
Myocardial ischemia
Neural networks
Physiology
Quality of life
Science
Science (multidisciplinary)
Single photon emission computed tomography
Stress
Tomography
Ventricle
Well being
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Summary:Extensive evidence highlights a robust connection between various forms of chronic stress and cardiovascular disease (CVD). In today's fast-paced world, with chronic stressors abound, CVD has emerged as a leading global cause of mortality. The intricate interplay of physical and psychological stressors triggers distinct neural networks within the brain, culminating in diverse health challenges. This study aims to discern the unique impacts of chronic physical and psychological stress on the cardiovascular system, unveiling their varying potencies in precipitating CVD. Twenty-one adolescent female rats were methodically assigned to three groups: (1) control (n = 7), (2) physical stress (n = 7), and (3) psychological stress (n = 7). Employing a two-compartment enclosure, stressors were administered to the experimental rats over five consecutive days, each session lasting 10 min. After a 1.5-month recovery period post-stress exposure, a trio of complementary techniques characterized by high specificity or high sensitivity were employed to meticulously evaluate CVD. Echocardiography and single-photon emission computed tomography (SPECT) were harnessed to scrutinize left ventricular architecture and myocardial viability, respectively. Subsequently, the rats were ethically sacrificed to facilitate heart removal, followed by immunohistochemistry staining targeting glial fibrillary acidic protein (GFAP). Rats subjected to psychological stress showed a wider range of significant cardiac issues compared to control rats. This included left ventricular hypertrophy [IVSd: 0.1968 ± 0.0163 vs. 0.1520 ± 0.0076, P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-43721-7