Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

Recently, the metabolites separated from endophytes have attracted significant attention, as many of them have a unique structure and appealing pharmacological and biological potentials. Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a rev...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-01, Vol.25 (2), p.395
Main Authors: Noor, Ahmad Omar, Almasri, Diena Mohammedallam, Bagalagel, Alaa Abdullah, Abdallah, Hossam Mohamed, Mohamed, Shaimaa Gamal Abdallah, Mohamed, Gamal Abdallah, Ibrahim, Sabrin Ragab Mohamed
Format: Article
Language:English
Subjects:
biological activities
Biological activity
Biosynthesis
Carbon
Chemistry
dihydroisocoumarins
Endophytes
Fungi
isocoumarins
Isomers
Marine organisms
Metabolites
Natural products
Review
Structural analysis
Sulfur
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Summary:Recently, the metabolites separated from endophytes have attracted significant attention, as many of them have a unique structure and appealing pharmacological and biological potentials. Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a reversed lactone moiety. They are produced by plants, microbes, marine organisms, bacteria, insects, liverworts, and fungi and possessed a wide array of bioactivities. This review gives an overview of isocoumarins derivatives from endophytic fungi and their source, isolation, structural characterization, biosynthesis, and bioactivities, concentrating on the period from 2000 to 2019. Overall, 307 metabolites and more than 120 references are conferred. This is the first review on these multi-facetted metabolites from endophytic fungi.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25020395