The effects of varicocelectomy on the DNA fragmentation index and other sperm parameters: a meta-analysis

Varicocele is one of the most common causes of reversible male infertility, and 15% of the varicocele patients with normal semen analysis are diagnosed as infertile. According to the current guidelines, varicocelectomy is indicated based on abnormal sperm parameters and not abnormal DNA fragmentatio...

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Bibliographic Details
Published in:Basic and clinical andrology 2020-09, Vol.30 (1), p.15-15, Article 15
Main Authors: Birowo, Ponco, Rahendra Wijaya, J, Atmoko, Widi, Rasyid, Nur
Format: Article
Language:English
Subjects:
DNA fragmentation
Fertility
Infertility
Meta-analysis
Morphology
Motility
Pathophysiology
Review
Sperm
Sperm analysis
Surgical techniques
Varicocele
Varicocelectomy
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Summary:Varicocele is one of the most common causes of reversible male infertility, and 15% of the varicocele patients with normal semen analysis are diagnosed as infertile. According to the current guidelines, varicocelectomy is indicated based on abnormal sperm parameters and not abnormal DNA fragmentation index (DFI) values. Thus, in this study, we performed a meta-analysis of the effects of varicocelectomy on the DFI and other conventional sperm parameters, and determined whether DFI could be used to indicate varicocelectomy for varicocele patients. Through an electronic search of the PubMed, Scopus, EBSCO, and Cochrane databases, we included 7 prospective studies including a total of 289 patients in this meta-analysis. The results showed that varicocelectomy significantly reduced DNA fragmentation (mean difference: - 6.86; 95% confidence interval [CI]: - 10.04, - 3.69;  
ISSN:2051-4190
2051-4190
DOI:10.1186/s12610-020-00112-6