Myenteric Denervation of the Gut with Benzalkonium Chloride: A Review of Forty Years of an Experimental Model

Experimental denervation of organs plays a key role in understanding the functional aspects of the normal innervation as well as the diseases related to them. In 1978 the experimental model of myenteric denervation of the rat gut by serosal application of benzalkonium chloride (BAC) was proposed. BA...

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Bibliographic Details
Published in:Canadian journal of gastroenterology & hepatology 2019-01, Vol.2019 (2019), p.1-7
Main Authors: Kannen, Vinicius, Marques, Isabela de Souza, Minto, Stefânia Bovo, Garcia, Sergio Britto
Format: Article
Language:English
Subjects:
Apoptosis
Chloride
Digestive system
Endoscopy
Experiments
Medical research
Nervous system
Neurons
Pathology
Review
Rodents
Studies
Surgery
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Summary:Experimental denervation of organs plays a key role in understanding the functional aspects of the normal innervation as well as the diseases related to them. In 1978 the experimental model of myenteric denervation of the rat gut by serosal application of benzalkonium chloride (BAC) was proposed. BAC is a positively charged surface-active alkylamine and is a powerful cationic detergent, which destroys bacteria after ionic attraction and for this reason is largely used as a surgical antiseptic. Since its initial report, the BAC-induced myenteric denervation model has been used to study many functional and pathological aspects of the enteric nervous system. So far this is the only pure method of myenteric denervation available for research in this area. Promising reports in the literature have shed light on the possibilities for the development of new uses of the BAC-denervation experimental model as a therapeutic tool in some pathological situations. This review aims to shed light on the main historical and recent findings provided by this experimental model.
ISSN:2291-2789
2291-2797
DOI:10.1155/2019/3562492