Parthenin-A Sesquiterpene Lactone with Multifaceted Biological Activities: Insights and Prospects

Parthenin, a sesquiterpene lactone of pseudoguaianolide type, is the representative secondary metabolite of the tropical weed (Asteraceae). It accounts for a multitude of biological activities, including toxicity, allergenicity, allelopathy, and pharmacological aspects of the plant. Thus far, parthe...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-09, Vol.26 (17), p.5347
Main Authors: Kaur, Amarpreet, Kaur, Shalinder, Jandrotia, Rupali, Singh, Harminder Pal, Batish, Daizy Rani, Kohli, Ravinder Kumar, Rana, Virendra Singh, Shakil, Najam A
Format: Article
Language:English
Subjects:
Allelopathy
Allergenicity
Asteraceae - chemistry
Asteraceae - metabolism
Biocompatibility
Biological activity
Cancer
Chemists
Cytotoxicity
Enzymes
Leukemia
Metabolites
Natural products
Pesticides
pharmacological properties
Pharmacology
pseudoguaianolide
Review
sesquiterpene lactone
Sesquiterpenes - chemistry
Sesquiterpenes - metabolism
Sesquiterpenes - pharmacology
terpenoids
Toxicity
toxicology
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Summary:Parthenin, a sesquiterpene lactone of pseudoguaianolide type, is the representative secondary metabolite of the tropical weed (Asteraceae). It accounts for a multitude of biological activities, including toxicity, allergenicity, allelopathy, and pharmacological aspects of the plant. Thus far, parthenin and its derivatives have been tested for chemotherapeutic abilities, medicinal properties, and herbicidal/pesticidal activities. However, due to the lack of toxicity-bioactivity relationship studies, the versatile properties of parthenin are relatively less utilised. The possibility of exploiting parthenin in different scientific fields (e.g., chemistry, medicine, and agriculture) makes it a subject of analytical discussion. The present review highlights the multifaceted uses of parthenin, on-going research, constraints in the practical applicability, and the possible workarounds for its successful utilisation. The main aim of this comprehensive discussion is to bring parthenin to the attention of researchers, pharmacologists, natural product chemists, and chemical biologists and to open the door for its multidimensional applications.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26175347