The Significance of CXCL1 and CXCL8 as Well as Their Specific Receptors in Colorectal Cancer

Every year, almost 2 million people develop colorectal cancer (CRC), which makes it the fourth most common malignancy worldwide. It is also estimated that approximately 48% of CRC patients will die from the disease. Thus, noninvasive and accurate methods for early detection and prevention of CRC are...

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Bibliographic Details
Published in:Cancer management and research 2020-01, Vol.12, p.8435-8443
Main Authors: Lukaszewicz-Zajac, Marta, Paczek, Sara, Mroczko, Piotr, Kulczynska-Przybik, Agnieszka
Format: Article
Language:English
Subjects:
Analysis
Angiogenesis
biochemical diagnosis
Biomarkers
Cancer metastasis
Cell adhesion & migration
Chemokines
Colonoscopy
Colorectal cancer
Development and progression
Immune system
Inflammation
Kinases
Medical prognosis
Medical screening
Metastasis
Neutrophils
Pathogenesis
Patients
Proteins
Review
tumor biomarkers
Tumor necrosis factor-TNF
Wound healing
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Summary:Every year, almost 2 million people develop colorectal cancer (CRC), which makes it the fourth most common malignancy worldwide. It is also estimated that approximately 48% of CRC patients will die from the disease. Thus, noninvasive and accurate methods for early detection and prevention of CRC are sorely needed. It is suggested that C-X-C motif ligand 1 (CXCL1) and C-X-C motif ligand 8 (CXCL8) as well as their cognate receptors can mediate tumor growth, proliferation, survival, neoangiogenesis and metastasis of malignant cells, including CRC. However, little is known about the clinical significance of these proteins as potential biomarkers for CRC. Therefore, in our review, we performed a comprehensive literature search using the PubMed database to identify original articles that investigated whether CXCL1 and CXCL8 and their receptors play a role in CRC pathogenesis. In summary, our review highlighted the potential significance of CXCL1/CXCR2 and CXCL8/CXCR1,-2 in the diagnosis and progression of CRC as well as indicated their potential therapeutic significance. However, given the non-specific nature of analyzed che-mokines and a small number of studies concerning the assessment of blood concentration of these proteins in CRC patients, investigations need to be continued in the future before selected chemokines could be established as biomarkers for CRC. Keywords: biochemical diagnosis, chemokines, colorectal cancer, tumor biomarkers
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S267176