Is syndecan-2 a key angiogenic element?

Angiogenesis has been extensively related with the development of many different diseases, from tumor progression to cardiovascular disorders. In our last article, we demonstrated that syndecan-2, the most abundant heparan sulfate proteoglycan expressed by human microvascular endothelial cells, is r...

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Bibliographic Details
Published in:TheScientificWorld 2009-01, Vol.9, p.729-732
Main Authors: Noguer, O, Reina, M
Format: Article
Language:English
Subjects:
Angiogènesi
Animals
Cells, Cultured
Cercopithecus aethiops
COS Cells
Directions in Science
Diseases
Expressió gènica
Gene expression
Glicoproteïnes
Glycoproteins
Health aspects
Humans
Malalties
Membrane proteins
Neovascularization
Neovascularization, Physiologic - physiology
Physiological aspects
Syndecan-2 - physiology
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Summary:Angiogenesis has been extensively related with the development of many different diseases, from tumor progression to cardiovascular disorders. In our last article, we demonstrated that syndecan-2, the most abundant heparan sulfate proteoglycan expressed by human microvascular endothelial cells, is regulated by proangiogenic factors and plays an important role in most of the cellular events that take place in neovascularization processes. Here, we also reported its involvement in the reorganization of the cytoskeleton and propose a key role for this proteoglycan as an adaptor protein, able to work in cooperation with the integrins in the formation of new blood vessels.
ISSN:1537-744X
2356-6140
1537-744X
DOI:10.1100/tsw.2009.89