Zein as an Effective Carrier for Hesperidin Delivery Systems with Improved Prebiotic Potential

Hesperidin is a polyphenol derived from citrus fruits that has a broad potential for biological activity and the ability to positively modify the intestinal microbiome. However, its activity is limited by its low solubility and, thus, its bioavailability-this research aimed to develop a zein-based h...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-07, Vol.28 (13), p.5209
Main Authors: Sip, Szymon, Sip, Anna, Miklaszewski, Andrzej, Żarowski, Marcin, Cielecka-Piontek, Judyta
Format: Article
Language:English
Subjects:
Bacteria
Bioavailability
Biological activity
Biopolymers
Citrus
Citrus fruits
Controlled release
Delayed-Action Preparations
Diabetes
Excipients
extended-release
Flavonoids
Glucose
Glucosidase
Hesperidin
Hesperidin - pharmacology
improved solubility
Lactiplantibacillus
Membranes
Metabolism
microbiome
Microbiomes
Microbiota
Molecular weight
Permeability
Prebiotics
Probiotics
Solubility
Spectrum analysis
Sustained release
System effectiveness
Type 2 diabetes
Vibration
Zein
α-Glucosidase
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Summary:Hesperidin is a polyphenol derived from citrus fruits that has a broad potential for biological activity and the ability to positively modify the intestinal microbiome. However, its activity is limited by its low solubility and, thus, its bioavailability-this research aimed to develop a zein-based hesperidin system with increased solubility and a sustained release profile. The study used triple systems enriched with solubilizers to maximize solubility. The best system was the triple system hesperidin-zein-Hpβ-CD, for which the solubility improved by more than six times. A significant improvement in the antioxidant activity and the ability to inhibit α-glucosidase was also demonstrated, due to an improved solubility. A release profile analysis was performed in the subsequent part of the experiments, confirming the sustained release profile of hesperidin, while improving the solubility. Moreover, the ability of selected probiotic bacteria to metabolize hesperidin and the effect of this flavonoid compound on their growth were investigated.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28135209