Assessment of the genotoxic potential of soil-associated DDTs and its metabolites using the Salmonella/microsome assay

The study aimed to assess the genotoxicity of different DDT contaminated soils (with different amendment types) in benzene extracts. A Salmonella/microsome assay without metabolic activation (-S9) was performed to evaluate the efficiency to initiate the mutations of remediated and non-remediated soi...

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Bibliographic Details
Published in:BIO web of conferences 2024-04, Vol.100, p.3016
Main Authors: Turganova, Ronagul, Koishekenova, Gulshat, Zaypanova, Saule, Delannoy, Matthieu, Jurjanz, Stefan, Bekmanov, Bakhytzhan
Format: Article
Language:English
Subjects:
Agricultural sciences
Agronomy
Animal biology
Animal production studies
Environmental Engineering
Environmental Sciences
Food and Nutrition
Life Sciences
Soil study
Toxicology
Toxicology and food chain
Veterinary medicine and animal Health
Zootechny
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Summary:The study aimed to assess the genotoxicity of different DDT contaminated soils (with different amendment types) in benzene extracts. A Salmonella/microsome assay without metabolic activation (-S9) was performed to evaluate the efficiency to initiate the mutations of remediated and non-remediated soils. The number of revertants mutations in his+ in TA100 and TA98 strains were obtained, and compared to soils without DDT, and remediated DDT containing soils. The interpretation of the data suggests that, mutagenic activity was high for the non-remediated soils samples Kyzylkairat and Beskainar, and revealed in the scale as a weak mutagen. Soil samples treated with DARCO, ORBO, Sarg150μm in Kyzylkairat and Beskainar exhibited a decreasing level of mutagenic activity, which is in line with the decreased environmental availability in these soil. Overall, the study indicates that strains TA100 and TA98 are valuable tools for rapidly assessing the potential mutagenicity of soil contaminated with OCPs.
ISSN:2117-4458
2273-1709
2117-4458
DOI:10.1051/bioconf/202410003016