Bacterial Reverse Mutation Test of Verbenalin

Verbenalin is a compound found in herbs such as and . This study investigated whether verbenalin is safe by analyzing its mutagenicity. To examine the mutagenic potential of verbenalin, a bacterial reverse mutation test (Ames test) was conducted with and strains. Experiments with and without metabol...

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Bibliographic Details
Published in:Journal of pharmacopuncture 2022-12, Vol.25 (4), p.364-368
Main Authors: Shin, Hye Jeong, Lim, Yi Gun, Ha, Ji Su, Yang, Gabsik, Yook, Tae Han
Format: Article
Language:English
Subjects:
dementia
mutagenicity test
Original
verbenalin
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Summary:Verbenalin is a compound found in herbs such as and . This study investigated whether verbenalin is safe by analyzing its mutagenicity. To examine the mutagenic potential of verbenalin, a bacterial reverse mutation test (Ames test) was conducted with and strains. Experiments with and without metabolic activity were performed. The mean colony number was less than double that of the control. Growth inhibition and precipitation of verbenalin were not apparent in all strains at different concentrations regardless of metabolic activity. Verbenalin did not show any signs of mutagenicity in this study. Additional toxicity studies including repeated oral toxicity, reproductive toxicity, and carcinogenicity tests are needed.
ISSN:2093-6966
2234-6856
DOI:10.3831/KPI.2022.25.4.364