Cholesterol: A Gatekeeper of Male Fertility?

Cholesterol is essential for mammalian cell functions and integrity. It is an important structural component maintaining the permeability and fluidity of the cell membrane. The balance between synthesis and catabolism of cholesterol should be tightly regulated to ensure normal cellular processes. Ma...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2018-07, Vol.9, p.369-369
Main Authors: Sèdes, Lauriane, Thirouard, Laura, Maqdasy, Salwan, Garcia, Manon, Caira, Françoise, Lobaccaro, Jean-Marc A, Beaudoin, Claude, Volle, David H
Format: Article
Language:English
Subjects:
cholesterol
Endocrinology
Endocrinology and metabolism
fertility
Human health and pathology
Life Sciences
nuclear receptors
Reproductive Biology
spermatozoa
testis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cholesterol is essential for mammalian cell functions and integrity. It is an important structural component maintaining the permeability and fluidity of the cell membrane. The balance between synthesis and catabolism of cholesterol should be tightly regulated to ensure normal cellular processes. Male reproductive function has been demonstrated to be dependent on cholesterol homeostasis. Here we review data highlighting the impacts of cholesterol homeostasis on male fertility and the molecular mechanisms implicated through the signaling pathways of some nuclear receptors.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2018.00369