Interaction between the gut microbiome and mucosal immune system

The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic microbiomes. The commensal microbiome regulates the maturat...

Full description

Saved in:
Bibliographic Details
Published in:Military medical research 2017-04, Vol.4 (1), p.14-14, Article 14
Main Authors: Shi, Na, Li, Na, Duan, Xinwang, Niu, Haitao
Format: Article
Language:English
Subjects:
Bacteria
Digestive system
Gastrointestinal Microbiome - physiology
Homeostasis
Humans
Immune system
Immunity
Immunity, Innate - immunology
Immunity, Innate - physiology
Immunity, Mucosal - physiology
Inflammation
Intestines - immunology
Microbial Interactions - physiology
Microbiome
Microbiota
Microorganisms
Review
Small intestine
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic microbiomes. The commensal microbiome regulates the maturation of the mucosal immune system, while the pathogenic microbiome causes immunity dysfunction, resulting in disease development. The gut mucosal immune system, which consists of lymph nodes, lamina propria and epithelial cells, constitutes a protective barrier for the integrity of the intestinal tract. The composition of the gut microbiota is under the surveillance of the normal mucosal immune system. Inflammation, which is caused by abnormal immune responses, influences the balance of the gut microbiome, resulting in intestinal diseases. In this review, we briefly outlined the interaction between the gut microbiota and the immune system and provided a reference for future studies.
ISSN:2054-9369
2095-7467
2054-9369
DOI:10.1186/s40779-017-0122-9