Oxidative Stress in Canine Diseases: A Comprehensive Review

Oxidative stress (OS), defined as a disruption in redox balance favoring oxidants, has emerged as a major contributor to numerous diseases in human and veterinary medicine. While several reviews have explored the implication of OS in human pathology, an exhaustive review of the canine species is lac...

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Bibliographic Details
Published in:Antioxidants 2024-11, Vol.13 (11), p.1396
Main Authors: Blanca, Perez-Montero, María Luisa, Fermín-Rodriguez, Guadalupe, Miró, Fátima, Cruz-Lopez
Format: Article
Language:English
Subjects:
Animal nutrition
Antioxidants
Apoptosis
Biomarkers
Cardiac arrhythmia
Cardiovascular disease
Diseases
dog
Dogs
Enzymes
free radicals
Health aspects
Heart failure
Homeostasis
Hypoxia
Inflammation
Lipid peroxidation
Lipids
Oxidants
Oxidation
Oxidative stress
Parasitic diseases
Pathogenesis
Pathology
Physiological aspects
Physiology
Pollutants
Proteins
Radiation
redox
Review
Reviews
Veterinary medicine
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Summary:Oxidative stress (OS), defined as a disruption in redox balance favoring oxidants, has emerged as a major contributor to numerous diseases in human and veterinary medicine. While several reviews have explored the implication of OS in human pathology, an exhaustive review of the canine species is lacking. This comprehensive review aims to summarize the existing literature on the role of OS in canine diseases, highlighting its potentially detrimental effect on various organs and systems. Some inconsistencies among studies exist, likely due to varying biomarkers and sample types. However, there is substantial evidence supporting the involvement of OS in the development or progression of numerous canine disorders, such as cardiovascular, oncologic, endocrine, gastrointestinal, hematologic, renal, neurologic, infectious, and parasitic diseases, among others. Additionally, this review discusses the efficacy of antioxidant and pro-oxidant therapeutic agents for these conditions. Dietary interventions to counteract OS in dogs have gained significant attention in recent years, although further research on the topic is needed. This review aims to serve as a foundational resource for future investigations in this promising field.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox13111396