Airway microbiota correlated with pulmonary exacerbation in primary ciliary dyskinesia patients

PCD is a rare disease characterized by productive cough, rhinitis, and recurrent infections of the upper and lower airways. Because the diagnosis of PCD is often delayed, patients receive more antibiotics, experience a heavier financial burden, and have a worse prognosis; thus, it is very important...

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Bibliographic Details
Published in:Microbiology spectrum 2023-12, Vol.11 (6), p.e0221323-e0221323
Main Authors: Zhou, Weitao, Guo, Zhuoyao, Chen, Jinglong, Chen, Yao, He, Chen, Lu, Aizhen, Qian, Liling
Format: Article
Language:English
Subjects:
airway microbiota
Anti-Bacterial Agents - therapeutic use
Child
Clinical Microbiology
Humans
Kartagener Syndrome - diagnosis
Kartagener Syndrome - drug therapy
Lung
Microbiota
microbiota diversity
primary ciliary dyskinesia
pulmonary exacerbation
Research Article
Sputum - microbiology
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Summary:PCD is a rare disease characterized by productive cough, rhinitis, and recurrent infections of the upper and lower airways. Because the diagnosis of PCD is often delayed, patients receive more antibiotics, experience a heavier financial burden, and have a worse prognosis; thus, it is very important to identify the pathogeny and use the correct antibiotic. In this large single-center study of PCD microbiota, we identified an outline of the bacterial microbes from the respiratory tract; furthermore, we found that the microbiota diversity in pediatric sputum was richer than that in pediatric BALF through sequencing, indicating a heterogeneous community structure. The microbiota diversity and richness were lower during pulmonary exacerbation than during pulmonary stabilization. A significantly higher abundance of had a moderate distinguishing effect for lung exacerbation, which attracted more attention for the study of therapy in pediatric patients with PCD.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.02213-23