Dietary Insulin Index (DII) and Dietary Insulin load (DIL) and Caveolin gene variant interaction on cardiometabolic risk factors among overweight and obese women: a cross-sectional study

Studies have shown that Caveolin gene polymorphisms (CAV-1) are involved in chronic diseases, such as metabolic syndrome. Moreover, the dietary insulin index (DII) and dietary insulin load (DIL) have been shown to potentially elicit favorable effects on cardiovascular disease (CVD) risk. Therefore,...

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Published in:European journal of medical research 2024-01, Vol.29 (1), p.74-21, Article 74
Main Authors: Amiri Khosroshahi, Reza, Mirzababaei, Atieh, Setayesh, Leila, Bagheri, Reza, Heidari Seyedmahalleh, Mohammad, Wong, Alexei, Suzuki, Katsuhiko, Mirzaei, Khadijeh
Format: Article
Language:English
Subjects:
Blood pressure
Body composition
Body fat
Body mass index
Breastfeeding & lactation
Cardiometabolic Risk Factors
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - genetics
Caveolin
Caveolins
Chronic diseases
Chronic illnesses
Cross-Sectional Studies
Diabetes
Diet
Dietary insulin index (DII)
Dietary insulin load (DIL)
Disease
Female
Food
Food habits
Genes
Genetic aspects
Genetic polymorphisms
Glucose
High density lipoprotein
Humans
Insulin
Insulin resistance
Lipids
Metabolic syndrome
Metabolic Syndrome - genetics
Muscles
Nutrition research
Obesity
Obesity - genetics
Overweight
Overweight - genetics
Oxidative stress
Risk factors
Womens health
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Summary:Studies have shown that Caveolin gene polymorphisms (CAV-1) are involved in chronic diseases, such as metabolic syndrome. Moreover, the dietary insulin index (DII) and dietary insulin load (DIL) have been shown to potentially elicit favorable effects on cardiovascular disease (CVD) risk. Therefore, this study sought to investigate the effect of DII DIL and CAV-1 interaction on CVD risk factors. This cross-sectional study consisted of 333 overweight and obese women aged 18-48 years. Dietary intakes, DII, and DIL were evaluated using the 147-item food frequency questionnaire (FFQ). Serum profiles were measured by standard protocols. The CAV-1 rs 3,807,992 and anthropometric data were measured by the PCR-RFLP method and bioelectrical impedance analysis (BIA), respectively. Participants were also divided into three groups based on DII, DIL score, and rs3807992 genotype. This comparative cross-sectional study was conducted on 333 women classified as overweight or obese. Participants with A allele for the caveolin genotype and higher DII score showed significant interactions with high-density lipoprotein (HDL) (P for AA = 0.006 and P for AG = 0.019) and CRI-I (P for AA 
ISSN:2047-783X
0949-2321
2047-783X
DOI:10.1186/s40001-024-01638-5