Recent Trends in System-Scale Integrative Approaches for Discovering Protective Antigens Against Mycobacterial Pathogens

Mycobacterial infections are one of the deadliest infectious diseases still posing a major health burden worldwide. The battle against these pathogens needs to focus on novel approaches and key interventions. In recent times, availability of genome scale data has revolutionized the fields of computa...

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Bibliographic Details
Published in:Frontiers in genetics 2018-11, Vol.9, p.572-572
Main Authors: Rana, Aarti, Thakur, Shweta, Kumar, Girish, Akhter, Yusuf
Format: Article
Language:English
Subjects:
antigen discovery
diagnostic markers
Genetics
Mycobacterium
reverse vaccinology
vaccine
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Summary:Mycobacterial infections are one of the deadliest infectious diseases still posing a major health burden worldwide. The battle against these pathogens needs to focus on novel approaches and key interventions. In recent times, availability of genome scale data has revolutionized the fields of computational biology and immunoproteomics. Here, we summarize the cutting-edge 'omics' technologies and innovative system scale strategies exploited to mine the available data. These may be targeted using high-throughput technologies to expedite the identification of novel antigenic candidates for the rational next generation vaccines and serodiagnostic development against mycobacterial pathogens for which traditional methods have been failing.
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2018.00572