Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis

The oral microbiome plays an important role in the human microbial community and in maintaining the health of an individual. Imbalances in the oral microbiome may contribute to oral and systemic diseases. The progression of periodontal disease is closely related to the growth of bacteria, such as Po...

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Bibliographic Details
Published in:Scientific reports 2021-06, Vol.11 (1), p.11742-12, Article 11742
Main Authors: Miyoshi, Tomohiro, Oge, Shogo, Nakata, Satoshi, Ueno, Yuji, Ukita, Hidehiko, Kousaka, Reiko, Miura, Yuki, Yoshinari, Nobuo, Yoshida, Akihiro
Format: Article
Language:English
Subjects:
631/326/107
631/326/2565/547
Adult
Aged
Antibiosis
Bacteria
Bacterial Typing Techniques
Case-Control Studies
Female
Gemella - physiology
Gemella haemolysans
Hemolysis
Humanities and Social Sciences
Humans
Male
Microbiomes
Middle Aged
Mouth - microbiology
multidisciplinary
Oral cavity
Pathogens
Periodontal diseases
Periodontal Diseases - microbiology
Periodontitis
Porphyromonas gingivalis
Porphyromonas gingivalis - physiology
Saliva
Saliva - microbiology
Science
Science (multidisciplinary)
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Summary:The oral microbiome plays an important role in the human microbial community and in maintaining the health of an individual. Imbalances in the oral microbiome may contribute to oral and systemic diseases. The progression of periodontal disease is closely related to the growth of bacteria, such as Porphyromonas gingivalis , in the oral cavity. However, the pathogen growth mechanism specific to periodontal disease remains unknown. This study aimed to identify bacteria associated with periodontal health by focusing on hemolytic bacteria. Unstimulated saliva samples were collected from ten periodontitis patients and five healthy subjects to detect and identify the presence of hemolytic bacteria. The saliva of healthy subjects contained a higher proportion of G. haemolysans than saliva samples from patients with periodontitis. Growth inhibition assays indicated that the protein components contained in the culture supernatant of G. haemolysans directly suppressed the growth of P. gingivalis . This study shows that the presence of G. haemolysans in saliva is associated with periodontal health and that it inhibits the growth of P. gingivalis in vitro.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-91267-3