Prognostic significance of eosinophil-to-platelet ratio and C-reactive protein in predicting adverse events during acute exacerbations of chronic obstructive pulmonary disease: A comprehensive observational study

Biomarkers like sarcopenia, eosinopenia and C-reactive protein (CRP) may predict major adverse events including intubation, ICU admission, mortality and readmission in chronic obstructive pulmonary disease (COPD) exacerbations. We aimed to determine their prognostic utility and accuracy. This was a...

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Bibliographic Details
Published in:Lung India 2024-11, Vol.41 (6), p.442-446
Main Authors: Yogesh, M, Kadalarasu, D, Makwana, Naresh, Chatterjee, Iva S
Format: Article
Language:English
Subjects:
biomarker
Blood platelets
C-reactive protein
Chronic obstructive pulmonary disease
Complications and side effects
copd
eosinopenia
Eosinophils
exacerbation
Health aspects
Intubation
Lung diseases, Obstructive
Medical research
Medicine, Experimental
Mortality
Original
Physiological aspects
Prognosis
Sarcopenia
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Summary:Biomarkers like sarcopenia, eosinopenia and C-reactive protein (CRP) may predict major adverse events including intubation, ICU admission, mortality and readmission in chronic obstructive pulmonary disease (COPD) exacerbations. We aimed to determine their prognostic utility and accuracy. This was a prospective analysis of COPD patients hospitalised for acute exacerbation over one year. Patients with primary diagnoses other than COPD were excluded. Patients were screened to select a sample of 205 participants, with 55 experiencing adverse events including intubation, ICU admission, in-hospital mortality and 30-day readmission. Data on demographics, lung function, symptoms, nutrition, frailty, sarcopenia, eosinophil-to-platelet ratio (EPR) and CRP were extracted. Differences between groups were analysed using t-tests and regression modelling. EPR
ISSN:0970-2113
0974-598X
DOI:10.4103/lungindia.lungindia_49_24