Current Status of microRNA-Based Therapeutic Approaches in Neurodegenerative Disorders

MicroRNAs (miRNAs) are a key gene regulator and play essential roles in several biological and pathological mechanisms in the human system. In recent years, plenty of miRNAs have been identified to be involved in the development of neurodegenerative disorders (NDDs), thus making them an attractive o...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2020-07, Vol.9 (7), p.1698
Main Authors: Paul, Sujay, Bravo Vázquez, Luis Alberto, Pérez Uribe, Samantha, Roxana Reyes-Pérez, Paula, Sharma, Ashutosh
Format: Article
Language:English
Subjects:
Amyotrophic lateral sclerosis
Animals
Ataxia
Biosynthesis
Dementia
Dementia disorders
Disease
Efficiency
Frontotemporal dementia
Gene expression
Gene Transfer Techniques
Genetic engineering
Humans
Lethality
Lipids
MicroRNA
MicroRNAs
MicroRNAs - biosynthesis
MicroRNAs - genetics
MicroRNAs - therapeutic use
miRNA
miRNA delivery
miRNA therapeutics
Models, Biological
Nanoparticles
Neurodegeneration
Neurodegenerative diseases
Neurodegenerative Diseases - therapy
neurodegenerative disorders
Proteins
Review
Spinal muscular atrophy
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Summary:MicroRNAs (miRNAs) are a key gene regulator and play essential roles in several biological and pathological mechanisms in the human system. In recent years, plenty of miRNAs have been identified to be involved in the development of neurodegenerative disorders (NDDs), thus making them an attractive option for therapeutic approaches. Hence, in this review, we provide an overview of the current research of miRNA-based therapeutics for a selected set of NDDs, either for their high prevalence or lethality, such as Alzheimer's, Parkinson's, Huntington's, Amyotrophic Lateral Sclerosis, Friedreich's Ataxia, Spinal Muscular Atrophy, and Frontotemporal Dementia. We also discuss the relevant delivery techniques, pertinent outcomes, their limitations, and their potential to become a new generation of human therapeutic drugs in the near future.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells9071698