Early- versus late-onset Alzheimer's disease in clinical practice: cognitive and global outcomes over 3 years

• Published in: Alzheimer's research & therapy 2017-08, Vol.9 (1), p.70-70, Article 70
• Main Authors: Wattmo, Carina, Wallin, Åsa K
• Format: Article
• Language: English
• Subjects: Activities of Daily Living - psychology; Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease - complications; Alzheimer Disease - drug therapy; Alzheimer Disease - psychology; Alzheimer's disease; Apolipoproteins E - genetics; Cholinesterase inhibitors; Cholinesterase Inhibitors - therapeutic use; Clinical Medicine; Cognition; Cognition Disorders - etiology; Drug therapy; Early-onset Alzheimer's disease; Female; Forecasts and trends; Geriatrics; Geriatrik; Humans; Klinisk medicin; Late-onset Alzheimer's disease; Longitudinal Studies; Longitudinal study; Male; Medical and Health Sciences; Medical statistics; Medicin och hälsovetenskap; Mental Status Schedule; Middle Aged; Mixed-effects models; Neurologi; Neurology; Neuropsychological Tests; Outcome Assessment (Health Care); Patient outcomes; Predictors; Time Factors
• ISSN: 1758-9193; 1758-9193
• DOI: 10.1186/s13195-017-0294-2

Whether age at onset influences Alzheimer's disease (AD) progression and the effectiveness of cholinesterase inhibitor (ChEI) therapy is not clear. We aimed to compare longitudinal cognitive and global outcomes in ChEI-treated patients with early-onset Alzheimer's disease (EOAD) versus late-onset Alzheimer's disease (LOAD) in clinical practice. This 3-year, prospective, observational, multicentre study included 1017 participants with mild to moderate AD; 143 had EOAD (age at onset