May polyethylene glycol be the cause of anaphylaxis to mRNA COVID-19 vaccines?

Vaccination against coronavirus is essential to minimize the impact of the COVID-19 pandemic. Rare cases of anaphylaxis associated with the mRNA COVID-19 vaccines are being described, and the mechanisms involved in these reactions are poorly understood. A potential culprit agent of these vaccine-ind...

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Bibliographic Details
Published in:The World Allergy Organization journal 2021-04, Vol.14 (4), p.100532-100532, Article 100532
Main Authors: Giavina-Bianchi, Pedro, Kalil, Jorge
Format: Article
Language:English
Subjects:
Allergies
Anaphylaxis
BNT162b2 mRNA COVID-19 vaccine
Conflicts of interest
Contraindications
COVID-19 vaccines
Disease control
Drug dosages
Etiology
Food
Glycoproteins
Health services
Immediate hypersensitivity reaction
Immunization
Macrogol
mRNA vaccines
Pandemics
Polyethylene glycol
Polysorbate
Potassium
Severe acute respiratory syndrome coronavirus 2
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Summary:Vaccination against coronavirus is essential to minimize the impact of the COVID-19 pandemic. Rare cases of anaphylaxis associated with the mRNA COVID-19 vaccines are being described, and the mechanisms involved in these reactions are poorly understood. A potential culprit agent of these vaccine-induced anaphylaxis events is polyethylene glycol, which has been reported as a cause of anaphylaxis. However, a cause-effect association has not been demonstrated, and the cases of anaphylaxis to mRNA COVID-19 vaccines should be further investigated. In this scenario, the recommendations are inaccurate and can lead to misinterpretation. At the moment, a more accurate recommendation would be the contraindication of mRNA COVID-19 vaccines in patients with immediate hypersensitivity reaction to polyethylene glycol or polysorbate. Patients with history of anaphylaxis to other or unknown causes should be referred to an allergist-immunologist for further orientation.
ISSN:1939-4551
1939-4551
DOI:10.1016/j.waojou.2021.100532