Comparing the efficacy of a novel mucoadhesive patch containing Nigella sativa 10% with triamcinolone 0.1% in patients with erosive‐atrophic oral lichen planus: A pilot study

Objective This study evaluates the efficacy of a novel mucoadhesive patch containing Nigella sativa 10% extract compared to triamcinolone 0.1% in alleviating symptoms and reducing lesion severity in patients with erosive‐atrophic oral lichen planus. Methods and Materials A pilot study comprising two...

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Bibliographic Details
Published in:Clinical and experimental dental research 2024-06, Vol.10 (3), p.e886-n/a
Main Authors: Pakfetrat, Atessa, Delavarian, Zahra, Malakooti, Mahshid, Bagheri, Hossein, Esmaily, Habibollah, Ghorbani, Mahsa, Saeedi, Pooya
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Inflammatory Agents - administration & dosage
Dental schools
Drug delivery systems
Female
Humans
Lichen Planus, Oral - drug therapy
Male
Middle Aged
Moisture absorption
mucoadhesive patch
Nigella sativa
Nigella sativa - chemistry
oral lichen planus
Original
Pain Measurement
Patients
Performance evaluation
Pharmaceutical industry
Phytotherapy - methods
Pilot Projects
Plant Extracts - administration & dosage
Steroids
Treatment Outcome
triamcinolone
Triamcinolone - administration & dosage
Triamcinolone - therapeutic use
Triamcinolone Acetonide - administration & dosage
Triamcinolone Acetonide - therapeutic use
Ulcers
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Summary:Objective This study evaluates the efficacy of a novel mucoadhesive patch containing Nigella sativa 10% extract compared to triamcinolone 0.1% in alleviating symptoms and reducing lesion severity in patients with erosive‐atrophic oral lichen planus. Methods and Materials A pilot study comprising two groups, each with 10 patients, was conducted. The intervention group received mucoadhesive patches containing N. sativa 10% extract, while the control group received triamcinolone acetonide 0.1% patches. Pain and burning intensity, measured through visual analog scale, and lesion severity based on the Thongprasom scale were assessed weekly for 4 weeks. Descriptive records were kept for side effects and patient satisfaction. Results Pain and burning intensity decreased in both groups throughout the sessions, with the N. sativa group showing a greater reduction than the triamcinolone group. The reduction in burning intensity within each group was significant (p  .05). Lesion severity also decreased significantly in both groups (p 
ISSN:2057-4347
2057-4347
DOI:10.1002/cre2.886