Non-targeted proteomics of acute respiratory distress syndrome: clinical and research applications

Acute respiratory distress syndrome (ARDS) is characterized by refractory hypoxemia caused by accumulation of pulmonary fluid with a high mortality rate, but the underlying mechanism is not yet fully understood, causing absent specific therapeutic drugs to treat with ARDS. In recent years, more and...

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Bibliographic Details
Published in:Proteome science 2021-03, Vol.19 (1), p.5-5, Article 5
Main Authors: Wen, Xu-Peng, Zhang, Yue-Zhong, Wan, Qi-Quan
Format: Article
Language:English
Subjects:
ARDS
Biomarkers
Clinical applications
Disease
Edema
Genes
Genomics
Health aspects
Hypoxemia
Lavage
Mass spectrometry
Medical research
Medicine, Experimental
Mortality
Non-targeted proteomics
Pathogenesis
Permeability
Pneumonia
Proteins
Proteomics
Research methodology
Respiratory distress syndrome
Review
Scientific imaging
Study designs
Technology application
Therapeutic targets
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Summary:Acute respiratory distress syndrome (ARDS) is characterized by refractory hypoxemia caused by accumulation of pulmonary fluid with a high mortality rate, but the underlying mechanism is not yet fully understood, causing absent specific therapeutic drugs to treat with ARDS. In recent years, more and more studies have applied proteomics to ARDS. Non-targeted studies of proteomics in ARDS are just beginning and have the potential to identify novel drug targets and key pathways in this disease. This paper will provide a brief review of the recent advances in the application of non-targeted proteomics to ARDS.
ISSN:1477-5956
1477-5956
DOI:10.1186/s12953-021-00174-y