Aryl Hydrocarbon Receptor and Dioxin-Related Health Hazards-Lessons from Yusho

Poisoning by high concentrations of dioxin and its related compounds manifests variable toxic symptoms such as general malaise, chloracne, hyperpigmentation, sputum and cough, paresthesia or numbness of the extremities, hypertriglyceridemia, perinatal abnormalities, and elevated risks of cancer-rela...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-01, Vol.22 (2), p.708
Main Authors: Furue, Masutaka, Ishii, Yuji, Tsukimori, Kiyomi, Tsuji, Gaku
Format: Article
Language:English
Subjects:
2,3,4,7,8-pentachlorodibenzofuran
Abnormalities
Animals
Aromatic compounds
aryl hydrocarbon receptor
Chloracne
Congeners
Cough
Cysts
Cytokines
dioxin
Dioxins
Dioxins - poisoning
Drug delivery
Enzymes
Flavonoids
Gene expression
Health hazards
Humans
Hydrocarbons
Hyperpigmentation
Hypertriglyceridemia
Ligands
Oxidative stress
Paresthesia
PCB
Phytochemicals
Pollutants
polychlorinated biphenyl
Polychlorinated biphenyls
Polymorphism
Porphyrias - chemically induced
Porphyrias - metabolism
Proteins
Reactive oxygen species
Reactive Oxygen Species - metabolism
Receptors, Aryl Hydrocarbon - metabolism
Review
Rice bran oil
Rice Bran Oil - adverse effects
Signs and symptoms
Sputum
Toxicity
Transcription factors
Yusho
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Summary:Poisoning by high concentrations of dioxin and its related compounds manifests variable toxic symptoms such as general malaise, chloracne, hyperpigmentation, sputum and cough, paresthesia or numbness of the extremities, hypertriglyceridemia, perinatal abnormalities, and elevated risks of cancer-related mortality. Such health hazards are observed in patients with Yusho (oil disease in Japanese) who had consumed rice bran oil highly contaminated with 2,3,4,7,8-pentachlorodibenzofuran, polychlorinated biphenyls, and polychlorinated quaterphenyls in 1968. The blood concentrations of these congeners in patients with Yusho remain extremely elevated 50 years after onset. Dioxins exert their toxicity via aryl hydrocarbon receptor (AHR) through the generation of reactive oxygen species (ROS). In this review article, we discuss the pathogenic implication of AHR in dioxin-induced health hazards. We also mention the potential therapeutic use of herbal drugs targeting AHR and ROS in patients with Yusho.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22020708