Tau: The Center of a Signaling Nexus in Alzheimer's Disease

Tau is a microtubule-associated protein whose misfolding, hyper-phosphorylation, loss of normal function and toxic gain of function are linked to several neurodegenerative disorders, including Alzheimer's disease (AD). This review discusses the role of tau in amyloid-β (Aβ) induced toxicity in...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in neuroscience 2016-02, Vol.10, p.31-31
Main Authors: Khan, Shahzad S, Bloom, George S
Format: Article
Language:English
Subjects:
Alzheimer's disease
Alzheimer’s disease (AD)
Amyloid
Amyloid-β oligomers (AβOs)
Cell cycle
Dementia
Dopamine
Insects
Neurodegenerative diseases
Neurofibrillary tangles (NFTs)
Neurons
Pathogenesis
Phosphorylation
Protein folding
Proteins
Psychiatry
synaptic dysfunction
Tau phosphorylation
Tau protein
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tau is a microtubule-associated protein whose misfolding, hyper-phosphorylation, loss of normal function and toxic gain of function are linked to several neurodegenerative disorders, including Alzheimer's disease (AD). This review discusses the role of tau in amyloid-β (Aβ) induced toxicity in AD. The consequences of tau dysfunction, starting from the axon and concluding at somadendritic compartments, will be highlighted.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2016.00031