Endoscopically Injectable Shear‐Thinning Hydrogels Facilitating Polyp Removal

Submucosal elevation, the process of instilling material in the submucosal space for separation of the surface mucosa and deeper muscularis layer, is a significant aspect of the endoscopic mucosal resection of large lesions performed to facilitate lesion removal and maximize safety. Submucosal injec...

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Bibliographic Details
Published in:Advanced science 2019-10, Vol.6 (19), p.1901041-n/a
Main Authors: Pang, Yan, Liu, Jinyao, Moussa, Zaina L., Collins, Joy E., McDonnell, Shane, Hayward, Alison M., Jajoo, Kunal, Langer, Robert, Traverso, Giovanni
Format: Article
Language:English
Subjects:
Biocompatibility
endoscopically injectable
Endoscopy
Experiments
Fluids
Glycerol
Hydrogels
Polyps
removal of polyps
Rheology
shear‐thinning hydrogels
Sodium
submucosal
Tumors
Viscoelasticity
Viscosity
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Summary:Submucosal elevation, the process of instilling material in the submucosal space for separation of the surface mucosa and deeper muscularis layer, is a significant aspect of the endoscopic mucosal resection of large lesions performed to facilitate lesion removal and maximize safety. Submucosal injection, when applied, has historically been performed with normal saline, though this is limited by its rapid dissipation; solutions ideally need to be easily injectable, biocompatible, and provide a long‐lasting submucosal cushion with a desirable height. Here, reported is a new set of materials, endoscopically injectable shear‐thinning hydrogels, meeting these requirements because of their biocompatible components and ability to form a solid hydrogel upon injection. These findings are supported by evaluation in a large animal model and ultimately demonstrate the potential of these shear‐thinning hydrogels to serve as efficient submucosal injection fluids for cushion development. Given these unique characteristics, their broad application in mucosal resection techniques is anticipated. Normal saline is the main injection fluid used for endoscopic mucosal resection though limited by its rapid dissipation. A set of endoscopically injectable shear‐thinning hydrogels is reported, which are biocompatible and have the ability to form a solid hydrogel upon injection, as demonstrated in a large animal model.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.201901041