An AIE Metal Iridium Complex: Photophysical Properties and Singlet Oxygen Generation Capacity

Photodynamic therapy (PDT) has garnered significant attention in the fields of cancer treatment and drug-resistant bacteria eradication due to its non-invasive nature and spatiotemporal controllability. Iridium complexes have captivated researchers owing to their tunable structure, exceptional optic...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-12, Vol.28 (23), p.7914
Main Authors: Zhu, Weijin, Liu, Shengnan, Wang, Ziwei, Shi, Chunguang, Zhang, Qiaohua, Wu, Zihan, Li, Guangzhe, Zhu, Dongxia
Format: Article
Language:English
Subjects:
Active oxygen
aggregation-induced emission (AIE)
Apoptosis
Cancer
Care and treatment
Electric power production
Free radicals
Hydration
Investigations
iridium (III) complex
Ligands
Optical properties
phosphorescence
Photochemotherapy
Photodynamic therapy
Quinoline
Reactive oxygen species
singlet oxygen (1O2)
Solvents
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Summary:Photodynamic therapy (PDT) has garnered significant attention in the fields of cancer treatment and drug-resistant bacteria eradication due to its non-invasive nature and spatiotemporal controllability. Iridium complexes have captivated researchers owing to their tunable structure, exceptional optical properties, and substantial Stokes displacement. However, most of these complexes suffer from aggregation-induced quenching, leading to diminished luminous efficiency. In contrast to conventional photosensitizers, photosensitizers exhibiting aggregation-induced luminescence (AIE) properties retain the ability to generate a large number of reactive oxygen species when aggregated. To overcome these limitations, we designed and synthesized a novel iridium complex named in this study. It incorporates quinoline triphenylamine cyclomethylated ligands that confer AIE characteristics for . We systematically investigated the photophysical properties, AIE behavior, spectral features, and reactive oxygen generation capacity of . The results demonstrate that exhibits excellent optical properties with pronounced AIE phenomenon and robust capability for producing singlet oxygen species. This work not only introduces a new class of metal iridium complex photosensitizer with AIE attributes but also holds promise for achieving remarkable photodynamic therapeutic effects in future cellular experiments and biological studies.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28237914