Host-Guest Inclusion Complexes of Natural Products and Nanosystems: Applications in the Development of Repellents

Repellents are compounds that prevent direct contact between the hosts and the arthropods that are vectors of diseases. Several studies have described the repellent activities of natural compounds obtained from essential oils. In addition, these chemical constituents have been pointed out as alterna...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-04, Vol.27 (8), p.2519
Main Authors: Pena, Gueive Astur, da Costa Lopes, Anna Sylmara, de Morais, Sylvano Heleno Salgado, do Nascimento, Lidiane Diniz, Dos Santos, Fábio Rogério Rodrigues, da Costa, Kauê Santana, Alves, Cláudio Nahum, Lameira, Jerônimo
Format: Article
Language:English
Subjects:
Arthropods
Bioactive compounds
Biocompatibility
Biological Products - pharmacology
Controlled release
Delayed-Action Preparations
Environmental protection
Essential oils
Inclusion complexes
Insect Repellents - chemistry
Insect Repellents - pharmacology
Insects
intermolecular interactions
Lipids
Mosquitoes
nanoencapsulation
nanosystems
Natural products
natural repellents
Nature conservation
Oils & fats
Oils, Volatile - chemistry
Oils, Volatile - pharmacology
Organic chemistry
Pheromones
Polymers
Proteins
Repellents
Review
Shelf life
Supramolecular compounds
Thermal stability
Toxicity
Vectors
VOCs
Volatile organic compounds
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Summary:Repellents are compounds that prevent direct contact between the hosts and the arthropods that are vectors of diseases. Several studies have described the repellent activities of natural compounds obtained from essential oils. In addition, these chemical constituents have been pointed out as alternatives to conventional synthetic repellents due to their interesting residual protection and low toxicity to the environment. However, these compounds have been reported with short shelf life, in part, due to their volatile nature. Nanoencapsulation provides protection, stability, conservation, and controlled release for several compounds. Here, we review the most commonly used polymeric/lipid nanosystems applied in the encapsulation of small organic molecules obtained from essential oils that possess repellent activity, and we also explore the theoretical aspects related to the intermolecular interactions, thermal stability, and controlled release of the nanoencapsulated bioactive compounds.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27082519