Elevated PTTG1 predicts poor prognosis in kidney renal clear cell carcinoma and correlates with immunity

PTTG1 has been reported to be linked with the prognosis and progression of various cancers, including kidney renal clear cell carcinoma (KIRC). In this article, we mainly investigated the associations between prognosis, immunity, and PTTG1 in KIRC patients. We downloaded transcriptome data from the...

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Bibliographic Details
Published in:Heliyon 2023-02, Vol.9 (2), p.e13201-e13201, Article e13201
Main Authors: Zhang, Xinyu, Ji, Hao, Huang, Yeqing, Zhu, Bingye, Xing, Qianwei
Format: Article
Language:English
Subjects:
Immunity
Immunotherapy
Kidney renal clear cell carcinoma
Prognosis
PTTG1
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Summary:PTTG1 has been reported to be linked with the prognosis and progression of various cancers, including kidney renal clear cell carcinoma (KIRC). In this article, we mainly investigated the associations between prognosis, immunity, and PTTG1 in KIRC patients. We downloaded transcriptome data from the TCGA-KIRC database. PCR and immunohistochemistry were used, respectively, to validate the expression of PTTG1 in KIRC at the cell line and the protein levels. Survival analyses as well as univariate or multivariate Cox hazard regression analyses were used to prove whether PTTG1 alone could affect the prognosis of KIRC. The most important point was to study the relationship between PTTG1 and immunity. The results of the paper revealed that the expression levels of PTTG1 were elevated in KIRC compared with para-cancerous normal tissues, validated by PCR and immunohistochemistry at the cell line and the protein levels (P 
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2023.e13201