Association between urine pH and common uropathogens in children with urinary tract infections

Urinary tract infections (UTIs) are one of the most common pediatric infections. Our objective in this study is to investigate the association between urine pH and uropathogens in pediatric patients. The source population comprised 26 066 paired urinalysis (UA) and urine culture (UC) samples obtaine...

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Published in:Journal of microbiology, immunology and infection immunology and infection, 2021-04, Vol.54 (2), p.290-298
Main Authors: Lai, Huan-Cheng, Chang, Shih-Ni, Lin, Hsiao-Chuan, Hsu, Yu-Lung, Wei, Hsiu-Mei, Kuo, Chin-Chi, Hwang, Kao-Pin, Chiang, Hsiu-Yin
Format: Article
Language:English
Subjects:
Urinalysis
Urinary tract infections
Urine pH
Uropathogens
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Summary:Urinary tract infections (UTIs) are one of the most common pediatric infections. Our objective in this study is to investigate the association between urine pH and uropathogens in pediatric patients. The source population comprised 26 066 paired urinalysis (UA) and urine culture (UC) samples obtained from pediatric patients. We classified the paired UA–UC samples into UTI positive (N = 6348) and UTI negative (N = 19 718) according to the colony forming units corresponding to the sampling source. We included UTI positive patients with infection caused by a single species of pathogen (N = 5201) and frequency matched them with UTI negative patients (N = 4729) by age, sex, sampling source, and visit type. This study included 5201 pediatric patients with UTIs and found that urine with Proteus mirabilis or Pseudomonas aeruginosa demonstrated the least acidic pH (mean pH = 6.72 and 6.62, respectively), whereas urine with Escherichia coli or Klebsiella pneumoniae exhibited the most acidic pH (pH = 6.21 and 6.18). After stratifying the UTI samples by their pH range (
ISSN:1684-1182
1995-9133
DOI:10.1016/j.jmii.2019.08.002