Orofacial granulomatosis and diet therapy: a review of the literature and two clinical cases

Orofacial granulomatosis is a nonspecific term that contains a wide variety of granulomatous entities, which share a clinical and histopathological presentation. It manifests as persistent or recurrent orofacial swelling, amongst other findings. Idiopathic orofacial granulomatosis, characterized by...

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Bibliographic Details
Published in:Anais brasileiros de dermatología 2018-02, Vol.93 (1), p.80-85
Main Authors: Espinoza, Iris, Navarrete, Jorge, Benedetto, Juana, Borzutzky, Arturo, Roessler, Patricia, Ortega-Pinto, Ana
Format: Article
Language:English
Subjects:
Adolescent
Adult
Crohn disease
DERMATOLOGY
Diet therapy
Granulomatosis, orofacial
Granulomatosis, Orofacial - diagnosis
Granulomatosis, Orofacial - diet therapy
Granulomatosis, Orofacial - pathology
Humans
Immunoglobulin E - blood
Male
Melkersson-Rosenthal syndrome
Mouth Mucosa - pathology
Review
Skin Tests
Young Adult
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Summary:Orofacial granulomatosis is a nonspecific term that contains a wide variety of granulomatous entities, which share a clinical and histopathological presentation. It manifests as persistent or recurrent orofacial swelling, amongst other findings. Idiopathic orofacial granulomatosis, characterized by an absence of systemic granulomatous disease, is a diagnosis of exclusion. The main differential diagnosis is Crohn's disease. Its pathogenesis is unknown, however, it seems to be immune-mediated. Patch-test sensitivity to multiple allergens is well documented. Currently, therapeutic options consider restrictive diets, topical, intralesional, and systemic agents. First-line therapy is currently a matter of debate. We present a review of the value of diet therapy in this syndrome, along with two illustrative cases.
ISSN:0365-0596
1806-4841
1806-4841
DOI:10.1590/abd1806-4841.20185828