Outcome of Candida Parapsilosis Complex Infections Treated with Caspofungin in Children

• Published in: Mediterranean journal of hematology and infectious diseases 2016-09, Vol.8 (1), p.e2016042-e2016042
• Main Authors: Devrim, İlker, İşgüder, Rana, Ağın, Hasan, Ceylan, Gökhan, Ayhan, Yüce, Sandal, Özlem Sara, Sarı, Ferhat, Kara, Ahu, Düzgöl, Mine, Gülfidan, Gamze, Bayram, Nuri
• Format: Article
• Language: English
• Subjects: Antifungal agents; Candida parapsilosis complex, caspofungin, children; Original
• ISSN: 2035-3006; 2035-3006
• DOI: 10.4084/MJHID.2016.042

We aimed to evaluate the correlation of caspofungin E-tests with the prognosis and response to caspofungin therapy of Candida parapsilosis complex bloodstream infections in children hospitalized in a pediatric intensive care unit. All children who had C. parapsilosis complex bloodstream infections and who were treated with caspofungin were included in this retrospective study. For each patient, the following parameters, including all consecutive blood and central venous catheter (CVC) cultures, the duration between diagnosis and CVC removal, mortality rate, relapses of the C. parapsilosis complex infections as well as the demographic features, were recorded. The central venous catheter survival rate was 33.3% under caspofungin treatment. In 92.4 % of the patients, the negative culture was achieved within a median duration of 12.5 days. The rate of relapses was 18.9%. The overall mortality rate was 37.7% (20 of 53 patients), and the 30-days mortality rate was 7.5% (4 of 53 patients). There was no statistically significant difference between the groups with MIC