Biased Immunoglobulin Genes Rearrangement in Mantle Cell Lymphoma： Hints to Identify the Normal B-cell Counterpart

Mantle cell lymphoma （MCL） is an aggressive nonHodgkin＇s lymphoma, originating from naive B-cells. The blastoid MCL tumors often show complex cytogenetic aberrations. In this review, we summarized the data available on immunoglobulin heavy-chain （IgH） genes rearrangement for their importance in sugg...

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Bibliographic Details
Published in:Cancer biology & medicine 2011-06, Vol.8 (2), p.65-70
Main Authors: Zhang, Hui-lai, Wang, Hua-qing, Hao, Xi-shan, Capello, Daniela, Cogliatti, Sergio B., Bertoni, Francesco, Cavalli, Franco
Format: Article
Language:English
Subjects:
immunoglobulin genes
mantle cell lymphoma
MCL
Medicine
Medicine & Public Health
Oncology
somatic hypermutation
免疫球蛋白重链
基因重排
定正
淋巴瘤
细胞外
细胞遗传学
选择过程
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Summary:Mantle cell lymphoma （MCL） is an aggressive nonHodgkin＇s lymphoma, originating from naive B-cells. The blastoid MCL tumors often show complex cytogenetic aberrations. In this review, we summarized the data available on immunoglobulin heavy-chain （IgH） genes rearrangement for their importance in suggesting the MCL normal counterpart B-cell. Some new data suggesting an antigen selection process were also presented in this review.
ISSN:1674-5361
2095-3941
1868-324X
DOI:10.1007/s11805-011-0561-0