Effects of Fermented Polygonum cuspidatum on the Skeletal Muscle Functions

Plant extract fermentation is widely employed to enhance the nutritional and pharmaceutical value of functional foods. (Pc) contains flavonoids, anthraquinones, and stilbenes, imparting protective effects against inflammatory diseases, cancer, diabetes, and cardiovascular diseases. However, the effe...

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Published in:Nutrients 2024-01, Vol.16 (2), p.305
Main Authors: Kim, Young-Seon, Han, Ji-Hye, Lim, Chang-Hoon, Fang, Xue-Quan, Jang, Hyeock-Soon, Lee, Sang-Yun, Yim, Woo-Jong, Lim, Ji-Hong
Format: Article
Language:English
Subjects:
Animals
Anthraquinones
Antioxidants
Berries
Biosynthesis
Data analysis
emodin
Emodin - metabolism
Enzymes
Fallopia japonica
Fatty acids
Fermentation
Mice
Microorganisms
Muscle strength
Muscle, Skeletal - metabolism
Musculoskeletal system
Oxidation
Oxidative stress
Phytochemicals
Polygonum cuspidatum
resveratrol
Resveratrol - metabolism
Resveratrol - pharmacology
skeletal muscle
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Summary:Plant extract fermentation is widely employed to enhance the nutritional and pharmaceutical value of functional foods. (Pc) contains flavonoids, anthraquinones, and stilbenes, imparting protective effects against inflammatory diseases, cancer, diabetes, and cardiovascular diseases. However, the effects of fermented Pc on skeletal muscle strength remain unexplored. In this study, we generated fermented Pc using a complex of microorganisms containing spp. (McPc) and assessed its effects on muscle strength and motor function in mice. Compared to unfermented Pc water extract, elevated levels of emodin and resveratrol were noted in McPc. This was identified and quantified using UPLC-QTOF/MS and HPLC techniques. Gene expression profiling through RNA-seq and quantitative RT-PCR revealed that McPc administration upregulated the expression of genes associated with antioxidants, glycolysis, oxidative phosphorylation, fatty acid oxidation, and mitochondrial biogenesis in cultured C2C12 myotubes and the gastrocnemius muscle in mice. McPc significantly improved skeletal muscle strength, motor coordination, and traction force in mice subjected to sciatic neurectomy and high-fat diet (HFD). McPc administration exhibited more pronounced improvement of obesity, hyperglycemia, fatty liver, and hyperlipidemia in HFD mice compared to control group. These findings support the notion that emodin and resveratrol-enriched McPc may offer health benefits for addressing skeletal muscle weakness.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu16020305