The value of elevated cerebrospinal fluid lactate concentrations in post-neurosurgical bacterial meningitis

Bacterial meningitis is a serious complication after neurosurgery and has a high mortality rate. Early diagnosis and timely treatment are crucial or will have disastrous consequences. The classic triad of bacterial meningitis lacks sensitivity and specificity. Therefore, the diagnosis of post-neuros...

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Bibliographic Details
Published in:BMC neurology 2023-10, Vol.23 (1), p.1-377, Article 377
Main Authors: Wang, Qin, Wang, YongFang, Yang, Yan, Kong, YanXi, Peng, Yuan
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
Bacterial meningitis
Care and treatment
Cerebrospinal fluid
Cerebrospinal fluid lactate
Cerebrospinal fluid parameters
Clinical medicine
Consciousness
Diagnosis
Diagnostic tests
Diagnostic value
Erythrocytes
Fever
Glucose
Infections
Lactic acid
Leukocytes
Medical examination
Medical laboratories
Meningitis
Metabolism
Mortality
Nervous system
Neurosurgery
Normal distribution
Patients
Post-neurosurgical bacterial Meningitis
Proteins
Puncture
Spine
Statistical analysis
Surgery
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Summary:Bacterial meningitis is a serious complication after neurosurgery and has a high mortality rate. Early diagnosis and timely treatment are crucial or will have disastrous consequences. The classic triad of bacterial meningitis lacks sensitivity and specificity. Therefore, the diagnosis of post-neurosurgical bacterial meningitis relies on cerebrospinal fluid. But traditional cerebrospinal fluid parameters are not completely reliable in diagnosing post-neurosurgical bacterial meningitis. Previous studies have found that CSF lactate concentration is related to bacterial meningitis. But, after the craniocerebral operation, the cerebrospinal fluid of most patients is bloody. Whether red blood cells interfere with diagnosing PNBM based on lactate concentration is limited. In the current study, we further analysis on whether red blood cells interfere with diagnosing PNBM based on lactate concentration. This study aimed to investigate the value of cerebrospinal fluid lactate concentrations in post-neurosurgical bacterial meningitis. A prospective observational study was performed on 62 patients at Kunshan First People’s Hospital’s intensive care unit affiliated with Jiangsu University. We found that erythrocytes do not affect cerebrospinal fluid lactate, and elevated lactate concentrations can be used as a marker for postoperative bacterial meningitis.
ISSN:1471-2377
1471-2377
DOI:10.1186/s12883-023-03428-8