Raman Spectroscopy to Characterize Bladder Tissue for Multidimensional Diagnostics of Cancer in Urology

Fiber optic Raman spectroscopy offers labelfree identification of cancer in the bladder under in vivo conditions. However, state-of-the-art Raman technology does not enable to scan the entire bladder wall. Our multidimensional approach within the project Uro-MDD combines panoramic 3D-image reconstru...

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Bibliographic Details
Published in:Current directions in biomedical engineering 2020-09, Vol.6 (3), p.250-253
Main Authors: Krafft, C., Guo, S., Bocklitz, T., Popp, J., Bronsert, P., Miernik, A.
Format: Article
Language:English
Subjects:
cancer diagnosis
chemometric data analysis
endoscopy
Raman imaging
Raman spectroscopy
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Summary:Fiber optic Raman spectroscopy offers labelfree identification of cancer in the bladder under in vivo conditions. However, state-of-the-art Raman technology does not enable to scan the entire bladder wall. Our multidimensional approach within the project Uro-MDD combines panoramic 3D-image reconstruction of white light cystoscopy and fluorescence lifetime imaging to define regions of interest for Raman-assisted diagnostics. First Raman results are presented from human control and cancer bladder specimens that demonstrated how to obtain specific molecular information. Such Raman images can be used in a clinical setting to determine cancer margins and the resection status. Fiber probes are under development to translate the technique to in vivo screening.
ISSN:2364-5504
2364-5504
DOI:10.1515/cdbme-2020-3063