Targeted pathophysiological treatment of ischemic stroke using nanoparticle-based drug delivery system

Ischemic stroke poses significant challenges in terms of mortality and disability rates globally. A key obstacle to the successful treatment of ischemic stroke lies in the limited efficacy of administering therapeutic agents. Leveraging the unique properties of nanoparticles for brain targeting and...

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Bibliographic Details
Published in:Journal of nanobiotechnology 2024-08, Vol.22 (1), p.499-32
Main Authors: Liu, Wei, Liu, Lubin, Li, Hong, Xie, Yutong, Bai, Ju, Guan, Jialiang, Qi, Hongzhao, Sun, Jinping
Format: Article
Language:English
Subjects:
Animals
Blood-Brain Barrier - metabolism
Brain - metabolism
Brain Ischemia - drug therapy
Drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Drug targeting
Drug therapy
Drugs
Health aspects
Humans
Ischemic stroke
Ischemic Stroke - drug therapy
Methods
Nanomedicine - methods
Nanoparticle
Nanoparticle Drug Delivery System - chemistry
Nanoparticles
Nanoparticles - chemistry
Neuroprotective Agents - chemistry
Neuroprotective Agents - therapeutic use
Oxidative Stress - drug effects
Pathophysiology
Review
Stroke (Disease)
Target therapy
Vehicles
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Summary:Ischemic stroke poses significant challenges in terms of mortality and disability rates globally. A key obstacle to the successful treatment of ischemic stroke lies in the limited efficacy of administering therapeutic agents. Leveraging the unique properties of nanoparticles for brain targeting and crossing the blood-brain barrier, researchers have engineered diverse nanoparticle-based drug delivery systems to improve the therapeutic outcomes of ischemic stroke. This review provides a concise overview of the pathophysiological mechanisms implicated in ischemic stroke, encompassing oxidative stress, glutamate excitotoxicity, neuroinflammation, and cell death, to elucidate potential targets for nanoparticle-based drug delivery systems. Furthermore, the review outlines the classification of nanoparticle-based drug delivery systems according to these distinct physiological processes. This categorization aids in identifying the attributes and commonalities of nanoparticles that target specific pathophysiological pathways in ischemic stroke, thereby facilitating the advancement of nanomedicine development. The review discusses the potential benefits and existing challenges associated with employing nanoparticles in the treatment of ischemic stroke, offering new perspectives on designing efficacious nanoparticles to enhance ischemic stroke treatment outcomes.
ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-024-02772-2