Effect of ketorolac tromethamine combined with dezocine prior administration on hemodynamics and postoperative analgesia in patients undergoing laparoscopic hernia repair

To observe the effect of Ketorolac tromethamine combined with dezocine prior administration on hemodynamics and postoperative sedation in patients undergoing laparoscopic hernia repair. 100 male patients aged 60 to 80 years old, a line to elective laparoscopic inguinal hernia repair, were randomly d...

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Published in:Medicine (Baltimore) 2022-05, Vol.101 (20), p.e29320-e29320
Main Authors: Wu, Yu, Cai, Zenghua, Li, Yanli, Kang, Yuling, Fu, Bohan, Wang, Jinbao
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Analgesia
Bridged Bicyclo Compounds, Heterocyclic
Clinical Trial/Experimental Study
Hemodynamics
Hernia, Inguinal - surgery
Herniorrhaphy
Humans
Ketorolac
Ketorolac Tromethamine - therapeutic use
Laparoscopy
Male
Middle Aged
Propofol
Remifentanil
Sufentanil
Tetrahydronaphthalenes
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Summary:To observe the effect of Ketorolac tromethamine combined with dezocine prior administration on hemodynamics and postoperative sedation in patients undergoing laparoscopic hernia repair. 100 male patients aged 60 to 80 years old, a line to elective laparoscopic inguinal hernia repair, were randomly divided into four groups: control group (Group A) and dezocine group (Group B), ketorolac tromethamine group (Group C), ketorolac tromethamine combined with dezocine group (Group D). Patients were administrated with 0.1 mg/kg dezocine in Group B, 0.5 mg/kg ketorolac in Group C, 0.1 mg/kg dezocine, and 0.5 mg/kg ketorolac in Group D, and with an equal dose of normal saline in group A. The heart rate (HR) and mean arterial pressure (MAP) of patients in 4 groups were recorded at each time point as follows, T0 (enter the operating room), T1 (before skin resection), 10 min after pneumoperitoneum (T2), mesh placement (T3), and laryngeal mask extraction (T4). Operation time, awakening time (time from drug withdrawal to consciousness recovery), the dosage of propofol, sufentanil, remifentanil, and intraoperative vasoactive drug dosage were recorded to compare. Visual analog scale score and sedation Ramsay score were evaluated 1, 6, 12, and 24 hours after extubation. There was no significant difference in operation time, anesthesia recovery time, sufentanil dosage, and vasoactive drugs among all groups. The amount of propofol in Group B and D was less than that in Group A and C (P  .05). The amount of remifentanil in Group B, C, and D was less than that in Group A (P 
ISSN:0025-7974
1536-5964
1536-5964
DOI:10.1097/MD.0000000000029320