Temporal trends and long-term outcomes of radiofrequency ablation for hepatocellular carcinoma within the Milan criteria

No study has analysed the temporal trends of the long-term results and clinical characteristics of patients with hepatocellular carcinoma (HCC) treated using radiofrequency ablation (RFA). Therefore, we examined temporal trends of characteristics of patients and treatment-naïve HCCs within the Milan...

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Bibliographic Details
Published in:Scientific reports 2024-08, Vol.14 (1), p.19815-11
Main Authors: Jang, Se Young, Park, Soo Young, Kweon, Young Oh, Lee, Yu Rim, Ryeom, Hun Kyu, Cha, Jung Guen, Kim, Sungmin, Lee, Won Kee, Jo, Ae Jeong, Tak, Won Young
Format: Article
Language:English
Subjects:
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Ablation
Adult
Aged
Antiviral agents
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - surgery
Fatty liver
Female
Hepatitis
Hepatocellular carcinoma
Humanities and Social Sciences
Humans
Kaplan-Meier Estimate
Liver cancer
Liver diseases
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Male
Middle Aged
multidisciplinary
Neoplasm Recurrence, Local - epidemiology
Patients
Radiofrequency Ablation
Retrospective Studies
Science
Science (multidisciplinary)
Survival
Treatment Outcome
Trends
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Summary:No study has analysed the temporal trends of the long-term results and clinical characteristics of patients with hepatocellular carcinoma (HCC) treated using radiofrequency ablation (RFA). Therefore, we examined temporal trends of characteristics of patients and treatment-naïve HCCs within the Milan criteria treated by RFA over 20 years. We retrospectively analysed 1099 patients with HCC within the Milan criteria treated with percutaneous RFA from January 2000 to December 2019. The overall survival (OS), recurrence-free survival (RFS), and factors affecting survival and local tumor progression were analysed using the Kaplan‒Meier method and Cox proportional hazards model. A trend test was performed to analyse the changing trends in participants and treatment outcomes. The overall and RFS of patients improved during the later period. In addition, viral hepatitis-related HCC incidence decreased, whereas that of alcohol- or non-alcoholic fatty liver disease-related HCC increased from the earlier to the later period ( P for trend 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-70494-4