Enhancement of chlorpromazine efficacy in breast cancer treatment by 266 nm laser irradiation

Breast cancer remains a global health challenge, prompting interest in the anticancer properties of other drugs, including chlorpromazine (CPZ). This study presents a novel approach in breast cancer treatment using laser irradiated CPZ. CPZ dissolved in distilled water, was exposed to 266 nm laser i...

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Bibliographic Details
Published in:Scientific reports 2024-12, Vol.14 (1), p.30329-16
Main Authors: Udrea, Ana Maria, Staicu, Angela, Smarandache, Adriana, Andrei, Ionut Relu, Badea, Madalina Andreea, Avram, Speranta, Pascu, Mihail Lucian, Pirvulescu, Ruxandra Angela, Balas, Mihaela
Format: Article
Language:English
Subjects:
631/114
631/154
631/80
Actin
ADME-Tox
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antipsychotic drugs
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - radiotherapy
Cancer therapies
Cell Line, Tumor
Cell Survival - drug effects
Cell Survival - radiation effects
Chlorpromazine
Chlorpromazine - pharmacology
Cytotoxicity
Distilled water
Drug repositioning
Female
Global health
Humanities and Social Sciences
Humans
Irradiation
Laser radiation
Laser-irradiated drugs
Lasers
MCF-7 Cells
multidisciplinary
Public health
Reactive Oxygen Species - metabolism
Science
Science (multidisciplinary)
Ultraviolet radiation
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Summary:Breast cancer remains a global health challenge, prompting interest in the anticancer properties of other drugs, including chlorpromazine (CPZ). This study presents a novel approach in breast cancer treatment using laser irradiated CPZ. CPZ dissolved in distilled water, was exposed to 266 nm laser irradiation for varying durations, characterized by UV-Vis and FTIR spectroscopy, followed by drug-likeness and ADME-Tox predictions. In vitro assays evaluated the cytotoxicity and cellular effects on MCF-7 breast cancer cells, and compared with MCF-12 A healthy cell line. Laser irradiation altered CPZ molecular structure resulting in photoproducts with favourable drug-like properties and ADME-Tox profiles. In vitro evaluations demonstrate dose and irradiation time-dependent cytotoxicity against breast cancer cells, and reduced toxicity on healthy cell line. Significant alterations in F-actin organization, and excessive ROS generation were also proved, suggesting the potential of laser-modified CPZ for breast cancer therapy. This study introduces a novel approach to breast cancer treatment through laser irradiated CPZ, highlighting promising advancements in therapy and emphasizing the role of laser-generated compounds.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-82088-1