UVA-Triggered Drug Release and Photo-Protection of Skin

Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a &q...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2021-02, Vol.9, p.598717
Main Authors: Karisma, Vega Widya, Wu, Wei, Lei, Mingxing, Liu, Huawen, Nisar, Muhammad Farrukh, Lloyd, Matthew D, Pourzand, Charareh, Zhong, Julia Li
Format: Article
Language:English
Subjects:
caged iron chelators
Cell and Developmental Biology
drug delivery systems (DDS)
skin photo-protection
smart sunscreens
up-conversion nanoparticles
UVA-triggered drug release
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Summary:Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a "switch on- switch off" procedure. This review discusses the promising potential of UVA radiation as the light source of choice for photo-controlled drug release from a range of photo-responsive and photolabile nanostructures photo-isomerization, photo-cleavage, photo-crosslinking, and photo-induced rearrangement. In addition to its clinical use, we will also provide here an overview of the recent UVA-responsive drug release approaches that are developed for phototherapy and skin photoprotection.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2021.598717