The Production Processes and Biological Effects of Intravenous Immunoglobulin

Immunoglobulin is a highly diverse autologous molecule able to influence immunity in different physiological and diseased situations. Its effect may be visible both in terms of development and function of B and T lymphocytes. Polyclonal immunoglobulin may be used as therapy in many diseases in diffe...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2016-03, Vol.6 (1), p.15
Main Authors: Barahona Afonso, Ana Filipa, João, Cristina Maria Pires
Format: Article
Language:English
Subjects:
Antineoplastic Agents - adverse effects
Cell Proliferation - drug effects
Cell Survival - drug effects
Humans
immune modulation
immunoglobulin
Immunoglobulins, Intravenous - isolation & purification
Immunoglobulins, Intravenous - pharmacology
Immunoglobulins, Intravenous - therapeutic use
IVIg
IVIg production
Lymphopenia - drug therapy
Lymphopenia - etiology
molecular mechanisms
Radiotherapy - adverse effects
Review
T-Lymphocytes - cytology
T-Lymphocytes - drug effects
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Summary:Immunoglobulin is a highly diverse autologous molecule able to influence immunity in different physiological and diseased situations. Its effect may be visible both in terms of development and function of B and T lymphocytes. Polyclonal immunoglobulin may be used as therapy in many diseases in different circumstances such as primary and secondary hypogammaglobulinemia, recurrent infections, polyneuropathies, cancer, after allogeneic transplantation in the presence of infections and/or GVHD. However, recent studies have broadened the possible uses of polyclonal immunoglobulin showing that it can stimulate certain sub-populations of T cells with effects on T cell proliferation, survival and function in situations of lymphopenia. These results present a novel and considerable impact of intravenous immunoglobulin (IVIg) treatment in situations of severe lymphopenia, a situation that can occur in cancer patients after chemo and radiotherapy treatments. In this review paper the established and experimental role of polyclonal immunoglobulin will be presented and discussed as well as the manufacturing processes involved in their production.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom6010015