Experimental and Numerical Design and Evaluation of a Vibration Bioreactor using Piezoelectric Patches

In this present study, we propose a method for exposing biological cells to mechanical vibration. The motive for our research was to design a bioreactor prototype in which in-depth in vitro studies about the influence of vibration on cells and their metabolism can be performed. The therapy of cancer...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2019-01, Vol.19 (2), p.436
Main Authors: Valentin, David, Roehr, Charline, Presas, Alexandre, Heiss, Christian, Egusquiza, Eduard, Bosbach, Wolfram A
Format: Article
Language:English
Subjects:
Bacteria
Bioreactor
Bioreactors
Bone cancer
Cell biology
Electricity
Enginyeria mecànica
Finite element method
Fluid dynamics
Fluids
Frequency ranges
Laser Doppler vibrometer (LDV)
Mecànica de fluids
Metabolism
Màquines hidràuliques i de fluids
Numerical Analysis, Computer-Assisted
PZTp
Sensors
Signal Processing, Computer-Assisted
Strain gauges
Time Factors
Ultrasonic imaging
Ultrasonics
Ultrasound
Vibration
Vibration control
Àrees temàtiques de la UPC
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Summary:In this present study, we propose a method for exposing biological cells to mechanical vibration. The motive for our research was to design a bioreactor prototype in which in-depth in vitro studies about the influence of vibration on cells and their metabolism can be performed. The therapy of cancer or antibacterial measures are applications of interest. In addition, questions about the reaction of neurons to vibration are still largely unanswered. In our methodology, we used a piezoelectric patch (PZTp) for inducing mechanical vibration to the structure. To control the vibration amplitude, the structure could be excited at different frequency ranges, including resonance and non-resonance conditions. Experimental results show the vibration amplitudes expected for every frequency range tested, as well as the vibration pattern of those excitations. These are essential parameters to quantify the effect of vibration on cell behavior. Furthermore, a numerical model was validated with the experimental results presenting accurate results for the prediction of those parameters. With the calibrated numerical model, we will study in greater depth the effects of different vibration patterns for the abovementioned cell types.
ISSN:1424-8220
1424-8220
DOI:10.3390/s19020436