The Vascular Circadian Clock in Chronic Kidney Disease

Chronic kidney disease is associated with extremely high cardiovascular mortality. The circadian rhythms (CR) have an impact on vascular function. The disruption of CR causes serious health problems and contributes to the development of cardiovascular diseases. Uremia may affect the master pacemaker...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2021-07, Vol.10 (7), p.1769
Main Authors: Egstrand, Søren, Mace, Maria L., Olgaard, Klaus, Lewin, Ewa
Format: Article
Language:English
Subjects:
adhesion molecules
Aging
Animal behavior
Aorta
Atherosclerosis
Blood pressure
Calcification
Cardiovascular diseases
Cardiovascular system
ccl2
Cell cycle
Circadian rhythm
Circadian rhythms
Feedback
Fibroblasts
Gene expression
Hypothalamus
ICAM-1
inflammation
Kidney diseases
Lipids
Metabolism
Pacemakers
Pathology
Physiology
Review
Sleep
Smooth muscle
Uremia
vascular calcification
Vascular diseases
VCAM-1
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Summary:Chronic kidney disease is associated with extremely high cardiovascular mortality. The circadian rhythms (CR) have an impact on vascular function. The disruption of CR causes serious health problems and contributes to the development of cardiovascular diseases. Uremia may affect the master pacemaker of CR in the hypothalamus. A molecular circadian clock is also expressed in peripheral tissues, including the vasculature, where it regulates the different aspects of both vascular physiology and pathophysiology. Here, we address the impact of CKD on the intrinsic circadian clock in the vasculature. The expression of the core circadian clock genes in the aorta is disrupted in CKD. We propose a novel concept of the disruption of the circadian clock system in the vasculature of importance for the pathology of the uremic vasculopathy.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells10071769