Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing

Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wound...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-07, Vol.26 (13), p.4037
Main Authors: Chen, Xushan, Zhang, Huimin, Yang, Xin, Zhang, Wuhong, Jiang, Ming, Wen, Ting, Wang, Jie, Guo, Rui, Liu, Hanjiao
Format: Article
Language:English
Subjects:
Antibacterial activity
antibacterial hydrogel
Antimicrobial agents
Bacteria
Bacterial diseases
Biocompatibility
Biodegradability
Biodegradation
Biomaterials
Biomedical materials
Chitosan
Dextran
Dextrans
Hyaluronic acid
Hydrogels
infected burn wound
Infections
Medical dressings
Metabolism
Metal oxides
Microorganisms
Nanoparticles
Pore size
Silver
silver nanoparticles
Skin
Wound healing
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Summary:Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wounds. Oxidized dextran (ODex) and adipic dihydrazide grafted hyaluronic acid (HA-ADH) were prepared, mixed with quaternized chitosan (HACC) and silver nanoparticles to fabricate Ag@ODex/HA-ADH/HACC hydrogel. The hydrogel, composed of nature biomaterials, has a good cytocompatibility and biodegradability. Moreover, the hydrogel has an excellent antibacterial ability and presents fast healing for burn wounds compared with commercial Ag dressings. The Ag@ODex/HA-ADH/HACC hydrogel will be a promising wound dressing to repair burn wounds and will significantly decrease the possibility of bacterial infection.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26134037